Prof De’Broski Herbert, Associate Professor of Immunology, University of Pennsylvania

The long-term goal of the Herbert laboratory is to explore the cellular and molecular regulatory networks that control host immunity, inflammation, and tissue repair during parasitic helminth infection. Prof Herbert has been fascinated with gastrointestinal nematodes his entire life and as a cellular immunologist, his work has provided foundational insight(s) into the host-parasite interaction regarding the development of alternatively activated macrophages (M2), eosinophil effector functions, Type 2 innale lymphocytes (ILC2), and conventional T helper 2 cells (TH2). This seminar will discuss the latest advances in the realm of transgenic helminth generation and study, which has led to the discovery that helminth-specific CD4 T cells have an immunosuppressive and wound healing signature characterized by the epidermal growth factor ligand, Amphiregulin.